Liraglutide Intermediate Arg34-GLP-1(7-37)

Cas No. 204521-68-6
production method: genetic engineering,expressed by E.Coli
Molecular Formula: C151H228N42O47
Molecular Weight:3383.68
Sequence
H-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly-OH

Type: Intermediate
Grade Standard: Pharma Grade
Brand Name:zabcbio
Model Number: ABC203
water content≤5%
TFA content≤1%
Purity ≥ 98%;
individual impurity≤1%
assay(as is basis)≥90%;
Storage Temperature 2-8℃;
Packing Size 1G/Bottle, 10G/Bottle,50G/Bottle or at customers requirement.
COA:Available
Liraglutide side chain is available
On sale:products or technology transfer fee

Description

Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist used clinically to treat type 2 diabetes mellitus.

Function: Liraglutide is for the treatment of diabetes type 2.
For research use only. We do not sell to patients.

Advantage:

At present, our main expression system is fusion and tandem copy method expression,polypeptides with other special functions enzyme expressed syncretic by a repeated tandem expression, so that the product has a high expression level and avoids the toxicity caused by chemical synthesis.

Our unique and independent expression system established by our R&D team has been successful tested under the condition of 150L scale,it proves a high-density fermentation process can be industrially Large-scale applicated.The protease produced by self-expression can obtain more than 95% enzyme digestion efficiency, propeptide treatment, intermediate peptide purification, fat chain modification, fine purification and raw material preparation process.

The purity of the raw material dry powder is not less than 99%. The HPLC retention time and mass spectrometry molecular weight of the drug substance developed by us are completely consistent with the Novo Nordisk Victoza.
Third part lab tested The cell viability in vitro and PK & PD determination in monkeys, the pharmacokinetics,EC50 and glucagon control effect are consistent with the Novo Nordisk Victoza
according to 18mg: 3.0ml injection, one kilogram of raw materials can produce 50,000 injections .

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