Liraglutide API

ITEM:  Liraglutide API
Cas No. 204656-20-2
Product Name:Liraglutide API
production method: genetic engineering,,expressed by E.Coli
Molecular Formula:C172H265N43O51
Molecular Weight:3751.20
Type: API
Grade Standard:Pharma Grade
Brand Name:zabcbio
Model Number:ABC202
water content≤5%
TFA content≤1%
Purity ≥ 98%;
individual impurity≤0.5%
assay(as is basis)≥90%;
Storage Temperature 2-8℃;
Packing Size 1G/Bottle, 10G/Bottle,50G/Bottle or at customers reqirement.
Liraglutide side chain is availabble
On sale:products or technology transfer fee

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    Liraglutide API (NN2211) is a long-acting glucagon-like peptide-1 receptor agonist, binding to the same receptors as does the endogenous metabolic hormone GLP-1 that stimulates insulin secretion. Marketed under the brand name Victoza, it is an injectable drug developed by Novo Nordisk for the treatment of type 2 diabetes. In 2015, Novo Nordisk began marketing it in the U.S. and E.U. under the brand name Saxenda as a treatment for adults, who are obese or overweight with at least one weight-relatedcomorbid condition.


    Liraglutide improves control of blood glucose.It reduces meal-related hyperglycemia (for 24 hours after administration) by increasing insulin secretion (only) when required by increasing glucose levels, delaying gastric emptying, and suppressing prandial glucagon secretion.

    In common to various degrees with other GLP-1 receptor agonists, liraglutide has advantages over more traditional therapies for type 2 diabetes:

    1).It acts in a glucose-dependent manner, meaning it will stimulate insulin secretion only when blood glucose levels are higher than normal, preventing “overshoot”. Consequently, it shows negligible risk of hypoglycemia.

    2).It has the potential for inhibiting apoptosis and stimulating regeneration of beta cells (seen in animal studies).

    3).It decreases appetite and inhibits body weight gain, as shown in a head-to-head study versus glimepiride.

    4).It lowers blood triglyceride levels.


    1.Treating type 2 diabetes.
    2.Treating obesity.

    For research use only. We do not sell to patients.


    At present, our main expression system is  fusion  and tandem copy method expression ,polypeptides with other special functions enzyme expressed syncretic by repeated tandem expression, so that the product has a high expression level and avoids the toxicity caused by chemical synthesis.

    Our unique and independent expression system established by our R&D team has been successful tested under the condition of 150L scale,it proves a high-density fermentation process can be industrially Large-scale applicated.The protease produced by self-expression can obtain more than 95% enzyme digestion efficiency, propeptide treatment, intermediate peptide purification, fat chain modification, fine purification and raw material preparation process.

    The purity of the raw material dry powder is not less than 99%. The HPLC retention time and mass spectrometry molecular weight of the drug substance developed by us are completely consistent with the Novo Nordisk Victoza.

    Third part lab tested The cell viability in vitro and PK & PD determination in monkeys, the pharmacokinetics,EC50 and glucagon control effect are consistent with the Novo Nordisk Victoza

    according to 18mg: 3.0ml injection, one kilogram of raw materials can produce 50,000 injections .



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