3,6-dichloropyrazine-2-carbonitrile

Favipiravir is active against a broad range of influenza viruses, including A(H1N1)pdm09, A(H5N1) and the recently emerged coronavirus. It also inhibits influenza strains resistant to current antiviral drugs, and shows a synergistic effect in combination with oseltamivir, thereby expanding influenza treatment options.

The Favipiravir is specifically made to treat RNA viruses like coronavirus these are viruses whose main genetic material is RNA, rather than DNA. The drug stops some viruses from replicating by crippling the enzyme (a substance that gets chemical reactions going) called RNA polymerase, which builds RNA. Without that enzyme intact, the virus can’t duplicate its genetic material efficiently once inside a host cell, according to an article describing the drug that was published in 2017 in the journal Proceedings of the Japan Academy, Ser. B, Physical and Biological Sciences.

 

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    Product Name: 3,6-dichloropyrazine-2-carbonitrile

    CAS:356783-16-9

    FAVIPIRAVIR intermediatesCAS
    3,6-dichloropyrazine-2-carbonitrile356783-16-9
    6-bromo-3-hydroxypyrazine-2-carboxamide259793-88-9
    2-aminopropanediamide62009-47-6
    3-HYDROXYPYRAZINE-2-CARBOXAMIDE55321-99-8
    Assay98%min(HPLC)
    Molecular FormulaC5HCl2N3
    Molecular Weight (g/mol)173.988
    3,6-dichloropyrazine-2-carbonitrile cas 356783-16-9 Chemical Properties 
    Monoisotopic Mass172.954752 g/mol
    Density1.60±0.1 g/cm3 (20 ºC 760 Torr)
    Melting point184°C to 187°C
    Boiling Point262.0±35.0℃ (760 Torr)
    Flash Point112.3±25.9℃
    InChI KeyUZHXXRRBFJSFCV-UHFFFAOYSA-N
    SmilesC1=C(N=C(C(=N1)Cl)C#N)Cl
    SolubilityInsoluble in water.
    Physical statePowder
    ApplicationIntermediate in organic syntheses
    Exact Mass172.954758
    PSA49.57000
    LogP1.68
    Vapour Pressure0.0±0.5 mmHg at 25°C

    Storage Condition:Store in a cool, dry place. Store in a tightly closed container. Storage under a nitrogen blanket has been recommended

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